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KMID : 0356620160310010134
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Journal of Korean Society of Endocrinology
2016 Volume.31 No. 1 p.134 ~ p.141
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Glucose-Dependent Insulinotropic Peptide Level Is Associated with the Development of Type 2 Diabetes Mellitus
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:Suh Sung-Hwan
:Kim Mi-Yeon/:Kim Soo-Kyoung/:Hur Kyu-Yeon/:Park Mi-Kyoung/:Kim Duk-Kyu/:Cho Nam H./:Lee Moon-Kyu
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Abstract
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Background : Incretin hormone levels as a predictor of type 2 diabetes mellitus have not been fully investigated. Therefore, we measured incretin hormone levels to examine the relationship between circulating incretin hormones, diabetes, and future diabetes development in this study.
Methods : A nested case-control study was conducted in a Korean cohort. The study included the following two groups: the control group (n=149), the incident diabetes group (n=65). Fasting total glucagon-like peptide-1 (GLP-1) and total glucose-dependent insulinotropic peptide (GIP) levels were measured and compared between these groups.
Results : Fasting total GIP levels were higher in the incident diabetes group than in the control group (32.64±22.68 pmol/L vs. 25.54±18.37 pmol/L, P=0.034). There was no statistically significant difference in fasting total GLP-1 levels between groups (1.14±1.43 pmol/L vs. 1.39±2.13 pmol/L, P=0.199). In multivariate analysis, fasting total GIP levels were associated with an increased risk of diabetes (odds ratio, 1.005; P=0.012) independent of other risk factors.
Conclusion : Fasting total GIP levels may be a risk factor for the development of type 2 diabetes mellitus. This association persisted even after adjusting for other metabolic parameters such as elevated fasting glucose, hemoglobin A1c, and obesity in the pre-diabetic period.
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KEYWORD
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Gastric inhibitory polypeptide, Diabetes mellitus, type 2, Glucagon-like peptide 1
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